Bystander effect-mediated gene therapy of gliomas using genetically engineered neural stem cells
نویسندگان
چکیده
منابع مشابه
Genetically Engineered Mesenchymal Stem Cells Stably Expressing Green Fluorescent Protein
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OBJECTIVE The herpes simplex virus thymidine kinase (HSVtk)/ganciclovir suicide gene therapy system has been considered as one of the most promising therapeutic strategies for malignant gliomas. We have been using HSVtk gene-transduced neural stem cells (NSCtk) that possess an ability to migrate toward a tumor mass for the treatment of experimental brain tumors. In the present study, we evaluat...
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In our previous study, we successfully treated an established C6 brain tumor using neural stem cells transduced with the herpes simplex virus-thymidine kinase gene (HSVtk) and ganciclovir in the rat. In the present study, we investigated the use of mesenchymal stem cells (MSCs), obtained from adult rats and transduced with HSVtk (MSCtk cells), instead of neural stem cells because MSCs are much ...
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ژورنال
عنوان ژورنال: Cancer Gene Therapy
سال: 2005
ISSN: 0929-1903,1476-5500
DOI: 10.1038/sj.cgt.7700826